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[目的]探讨血清心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)检测对于手足口病合并心肌损害的临床意义。[方法]检测276例手足口病患儿血清cTnI、CK-MB水平,同时选择60例健康查体小儿作为对照组。[结果]手足口病患儿血清cTnI和CK-MB水平明显高于对照组(P﹤0.01);cTnI在诊断手足口病合并心肌炎的敏感度高于CK-MB;cTnI窗口时间明显高于CK-MB。[结论]手足口病患儿易合并心肌损害、心肌炎。血清cTnI、CK-MB对早期诊断手足口病心肌损害、心肌炎有重要意义,且cTnI测定在诊断手足口病合并心肌炎的价值更大。
[Objective] To investigate the clinical significance of serum cardiac troponin I (cTnI) and creatine kinase isoenzyme (CK-MB) detection in hand-foot-mouth disease with myocardial damage. [Method] The serum levels of cTnI and CK-MB in 276 children with hand-foot-mouth disease were detected and 60 healthy children were selected as the control group. [Results] The serum levels of cTnI and CK-MB in HFMD children were significantly higher than those in control group (P <0.01). The sensitivity of cTnI in diagnosing HFMD complicated with myocarditis was higher than that of CK-MB. The cTnI window time was significantly higher than CK -MB. [Conclusion] Children with hand-foot-mouth disease easily have myocardial damage and myocarditis. Serum cTnI, CK-MB for early diagnosis of hand-foot-mouth disease myocardial damage, myocarditis is of great significance, and cTnI determination in the diagnosis of hand-foot-mouth disease with greater value of myocarditis.