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目的检测2010年-2011年丽水市手足口病发病病原体并分析发病特征,为更好的做好手足口病防控提供科学依据。方法采用实时荧光定量PCR法检测681份疑似手足口病患者样本的人体肠道病毒通用型、柯萨奇病毒A组16型(Cox A16)和肠道病毒71型(EV71)核酸,对检测结果进行流行病学分析和病原学探讨。结果 2010年-2011年丽水市疾病预防控制中心检测疑似患者样本681例,确认手足口病545例;发病高峰位于每年5月～7月;发病人群主要为5岁以下儿童,其中又以3岁以下儿童所占比例最大;检出的病原体两年均以EV71为主,但2011年Cox A16和其它肠道病毒有上升趋势。结论 2010年-2011年丽水市手足口病发病季节明显;发病人群以5岁以下儿童为主;主要病原体为EV71、Cox A16以及其它肠道病毒。
Objective To detect the pathogens of hand-foot-mouth disease in Lishui city from 2010 to 2011 and analyze the features of the disease so as to provide a scientific basis for prevention and control of hand-foot-mouth disease. Methods 681 samples of human hand, foot and mouth disease were detected by real-time fluorescence quantitative PCR for the detection of universal human enterovirus, Cox A16 and EV71, Conduct epidemiological analysis and etiology. Results From 2010 to 2011, 681 samples of suspected patients were detected by Lishui Municipal Center for Disease Control and Prevention, 545 cases of hand-foot-mouth disease were confirmed. The peak incidence was in May-July each year. The incidence of the disease was mainly children under 5 years of age, of which 3 years The following children accounted for the largest proportion; the pathogens detected in both major EV71-based, but in 2011 Cox A16 and other enteric viruses are on the rise. Conclusion The incidence of hand, foot and mouth disease in Lishui from 2010 to 2011 is significant. The incidence of the disease is mainly in children under 5 years old. The main pathogens are EV71, Cox A16 and other enteroviruses.