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目的 :探讨糖化血红蛋白(Hb Alc)、血清胱抑素C(Cys C)和尿微量白蛋白(U-m Alb)联合检测对诊断老年糖尿病肾病的临床应用价值。方法 :选择我院2011年8月至2014年7月收治370例的糖尿病肾病患者(DN组)、124例单纯糖尿病患者(DM组)及80健康体检者(对照组)。同时检测三组血液中Hb Alc、Cys C和U-m Alb含量并进行相关性分析。结果 :DN组的Hb Alc、Cys C和U-m Alb水平均明显高于DM组和对照组,而DM组的三项指标也都显著高于对照组。相关性分析表明,Hb Alc、Cys C和U-m Alb水平均呈现着显著的正相关关系。结论 :Hb Alc、Cys C和U-m Alb水平可以作为诊断DN的重要指标,联合检测三者对于评估老年糖尿病早期肾功能损伤具有重要的临床意义。
Objective: To investigate the clinical value of combined detection of Hb Alc, Cys C and U-m Alb in the diagnosis of diabetic nephropathy in the elderly. Methods: A total of 370 diabetic nephropathy patients (DN group), 124 diabetic patients (DM group) and 80 healthy controls (control group) were selected from August 2011 to July 2014 in our hospital. The blood levels of Hb Alc, Cys C and U-m Alb in the three groups were also detected and their correlations were analyzed. Results: The levels of Hb Alc, Cys C and U-m Alb in DN group were significantly higher than those in DM group and control group, while those in DM group were also significantly higher than those in control group. Correlation analysis showed that Hb Alc, Cys C and U-m Alb levels showed a significant positive correlation. Conclusion: The levels of Hb Alc, Cys C and U-m Alb can be used as an important index in the diagnosis of DN. The combined detection of these three levels is of great clinical significance for the assessment of early renal impairment in elderly patients with diabetes mellitus.