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大量研究表明,肺脏是糖尿病攻击的“靶器官”之一,其损害主要涉及肺功能及病理学改变。糖尿病患者肺功能损害主要表现为限制性通气功能障碍、小气道功能减退和弥散功能异常。而糖尿病肺组织病理学改变主要表现为基底膜增厚和细胞外基质增生以及超微结构的改变。积极控制血糖水平及胰岛素和噻唑烷二酮类药物治疗可能改善糖尿病患者的肺功能。深入研究糖尿病肺部病变,有可能在防治糖尿病血管并发症方面提出新的思路。
A large number of studies have shown that the lungs are one of the “target organs” for the attack of diabetes. The damage is mainly related to lung function and pathological changes. Pulmonary dysfunction in diabetic patients mainly manifested as restrictive ventilatory dysfunction, small airway dysfunction and diffuse dysfunction. Pathological changes of diabetic lung tissue mainly manifested as basement membrane thickening and extracellular matrix proliferation and ultrastructure changes. Positive control of blood glucose levels and insulin and thiazolidinedione therapy may improve lung function in diabetic patients. In-depth study of diabetic lung disease, it is possible to put forward new ideas in the prevention and treatment of diabetic vascular complications.