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目的探讨PTA联合自体外周血干细胞(APBSC)输注治疗糖尿病足(DF)的方法并观察近期临床效果。方法对11例自愿接受PTA联合APBSC移植的DF患者进行细胞动员5～7d;采用CS-3000单个核细胞分离机采集MNC,总采集量在90～145ml。局麻下行双侧肢体动脉DSA检查,对狭窄或闭塞血管PTA后经导管注入APBSC悬液。结果治疗后3～14d,ABI增加总效率86.67%。9例9只患肢的溃疡面改善总有效率为77.78%。3例坏疽1例愈合,1例好转,1例行截趾术,切口一期愈合。结论 PTA联合APBSC移植治疗DF是一种简便、安全、有效的治疗方法 ,其治疗的近期疗效令人满意。
Objective To investigate the method of PTA combined with autologous peripheral blood stem cell (APBSC) infusion in the treatment of diabetic foot (DF) and to observe the short-term clinical effect. Methods Cell mobilization was performed in 11 cases of DF patients who received PTA combined with APBSC voluntarily for 5-7 days. MNC was collected by CS-3000 mononuclear cell separator with total collection volume of 90-145 ml. Local anesthesia bilateral bilateral arterial DSA examination of the stenosis or occlusion of PTA catheter into the APBSC suspension. Results 3 to 14 days after treatment, ABI increased the total efficiency of 86.67%. The total effective rate of improvement of ulcer surface in 9 cases of 9 limbs was 77.78%. In 3 cases, gangrene was healed in 1 case, 1 case improved, and 1 case had phalanges. The incisions healed in one case. Conclusion The combination of PTA and APBSC in the treatment of DF is a simple, safe and effective treatment and the short-term curative effect is satisfactory.