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目的 :探讨不同海拔高原低氧环境对青藏铁路沿线筑路工人全血 5-羟色胺的影响 ;方法 :采用荧光技术测定北京组、西宁组 (海拔 2 2 60m)、格尔木 (海拔 2 850m)、昆仑山口 (海拔 50 50m)筑路工人在重体力劳动负荷下 ,全血 5-羟色胺的变化 ;结果 :随海拔的升高、氧分压下降 ,筑路工人劳动时间和劳动强度与 2 2 60m筑路工相等 ,但劳动效率明显降低 ,全血 5-羟色胺含量梯度增高 ;移居 2 850m、50 50m的两组筑路工与 2 2 60m比较 ,t值分别为 2 .3 8和 3 .1 8,P <0 .0 1 ;结论 :高原低氧加之重体力劳动是导致全血 5-羟色胺单胺递质变化的主要因素。
Objective: To investigate the effect of different altitude hypoxia environment on serotonin in whole blood of road construction workers along the Qinghai-Tibet Railway. Methods: Fluorescence technique was used to determine the concentration of serotonin in Beijing, Xining (elevation 2260m), Golmud (elevation 2 850m) Mountain Pass (50 50m above sea level) road workers under heavy manual work load, whole blood serotonin changes; Results: With the elevation of oxygen partial pressure decreased, road workers working hours and labor intensity and 2 2 60m However, the labor efficiency was significantly reduced, and the serotonin concentration gradient increased. The two road building workers who migrated to 2 850 m and 50 50 m had a t value of 2.38 and 3.18 respectively , P <0.01; Conclusions: High altitude hypoxia combined with heavy manual labor are the main factors leading to the change of serotonin monoamine neurotransmitters in whole blood.