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用EB病毒转化微量全血法建立了一对具高SCE特征的习惯流产夫妇的B淋巴母细胞株：JMSW-1，JMSW-2。细胞株平均倍增时间分别为45．5小时／代；48小时／代。常规染色体核型分析为正常核型且均保持高SCE特征。JMSW－1自发SCE为14．00次／每细胞，JMSW－2自发SCE为13．28次／每细胞。微核率分别为24．5‰；，20．5‰，加0．01μg／ml丝裂霉素C（MMC）处理，诱发SCE及微核率与正常细胞株相比均显著升高。JMSW－1诱发SCE为23．58次／每细胞，微核率42‰；JMSW-2诱发SCE为22．72次／每细胞，微核率39．5％；，夫妇双方自发、诱发SCE均高于正常对照组（P＜0．01）。
A B-lymphoblastoid cell line was established with a couple of conventional abortion couples with high SCE characteristics using Epstein-Barr virus transformation micro-whole blood method: JMSW-1, JMSW-2. The average cell doubling time were 45.5 hours / generation; 48 hours / generation. Conventional karyotype analysis was normal karyotype and maintained high SCE characteristics. The spontaneous SCE of JMSW-1 was 14.00 cells / cell, and the spontaneous SCE of JMSW-2 was 13.28 cells / cell. The micronuclei rates were 24.5 ‰ and 20.5 ‰, respectively. The addition of 0.01 μg / ml MMC increased the SCE and micronucleus rates significantly compared with those of normal cell lines. JMSW-1 induced SCE was 23.58 times per cell, micronucleus rate was 42 ‰; JMSW-2 induced SCE was 22.72 times per cell, micronucleus rate was 39.5%; both spontaneous and induced SCE Higher than the normal control group (P <0.01).