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目的了解上海市浦东新区腹泻患者中非伤寒沙门菌血清分型分布及耐药情况。方法 2011—2014年对浦东新区12家腹泻病监测点病例样本进行非伤寒沙门菌检测,分析菌株血清型及耐药表型特征。结果 7 626件样本中分离出360株非伤寒沙门菌,总检出率为4.7%,分属7个血清群,38个血清型,主要血清型为肠炎、鼠伤寒。对萘啶酸的耐前率为44.5%~60.7%,对氨苄西林的耐药率为31.3%~49.2%;链霉素为27.3%~57.4%。对头孢他啶、氧氟沙星、阿莫西林/克拉维酸、庆大霉素敏感(耐药率均低于10%。多重耐药菌达35.6%。结论浦东新区非伤寒沙门菌腹泻株以肠炎、鼠伤寒沙门菌为主。抗生素耐药性呈现多样性,多重耐药率呈逐年上升趋势,持续性监测具有重要意义。
Objective To understand the serotyping and drug resistance of non-typhoid Salmonella in diarrhea patients in Pudong New Area of Shanghai. Methods From 2011 to 2014, Salmonella typhimurium was detected in 12 cases of diarrheal disease surveillance in Pudong New Area, and the serotypes and drug resistance phenotypes of the strains were analyzed. Results A total of 360 strains of non-typhoid Salmonella isolated from 7 626 samples, with a total detection rate of 4.7%. They belonged to 7 serogroups and 38 serotypes. The major serotypes were enteritis and typhoid fever. The rate of prenatal resistance to nalidixic acid was 44.5% -60.7%, the rate of resistance to ampicillin was 31.3% -49.2%, and that of streptomycin was 27.3% -57.4%. The susceptibility to ceftazidime, ofloxacin, amoxicillin / clavulanic acid and gentamicin were all less than 10% and 35.6% respectively.Conclusion The non-typhoid salmonella diarrhea strain in Pudong New Area is dominated by enteritis , And Salmonella typhimurium.Distinctly, the antibiotic resistance is diversified, the multi-drug resistance rate is increasing year by year, and the continuous monitoring is of great significance.