十多年来由于过多使用 ACTH 或皮质类固醇制剂。随之在停药后出现了许多症状,甚至造成停药困难,最严重者为下丘脑-垂症-肾上腺皮质(HPA)功能受抑制。作者观察一组长期服用皮质类固醇,每日剂量相当强的松10～60mg,疗程从1.6～20年不等的病人。采用竞争性蛋白结合放射测定法以检查血浆考的松浓度,以 Glenn 和 Nelson氏法测定24小时尿17-酮(17-KS)和尿17- For more than a decade due to excessive use of ACTH or corticosteroid preparations. Followed by withdrawal after a lot of symptoms, and even caused withdrawal difficulties, the most severe hypothalamic - pituitary - adrenal (HPA) function was inhibited. The authors observed a group of long-term use of corticosteroids, a very strong daily dose of 10 ~ 60mg, treatment from 1.6 to 20 years of patients. The competitive plasma protein-binding radiometric assay was used to examine plasma testosterone concentrations and 24-hour urinary 17-keto (17-KS) and urinary 17-