已烯雌酚,一种合成非甾族类雌激素,用于预防流产和妊娠并发症,如早产、死胎和妊娠中毒症。1971年,流行病学研究认为阴道透明细胞腺癌和胎内受已烯雌酚影响有关。卧床最为关心的是多发性非恶性畸形,这些畸形在母体接受已烯雌酚的后裔中是很普遍的。文献已大量报导妇女下生殖道畸形,称为“已烯雌酚变化”(外翻、腺病、突冠、鸡冠、隆起等);子宫输卵管造影研究也发现有子宫结构改变;也曾提到宫颈上皮内瘤样病变的发生率增高。虽然曾经主张用局部破坏性方法,例如烧灼、冷冻、和切除来纠正这些阴道和宫颈畸形,事实证明,除非很谨慎,这些方法对母体曾接受已 Diethylstilbestrol, a synthetic non-steroidal estrogen, is used to prevent miscarriage and pregnancy complications such as premature birth, stillbirth and gestosis. In 1971, epidemiological studies suggest that vaginal clear cell adenocarcinoma and fetal effects by diethylstilbestrol. Of greatest concern for bed rest are multiple non-malignant deformities that are common in males receiving DES. Literature has reported a large number of women under the genital tract deformity, known as “changes in diethylstilbestrol” (valgus, adenosis, crown, cockscomb, uplift, etc.); hysterosalpingography study also found changes in the uterus; also mentioned Cervical intraepithelial neoplasia lesions increased the incidence. Although it has been suggested that these vaginal and cervical deformities be corrected by locally destructive methods, such as cauterization, freezing, and resection, it turns out that unless prudent these methods have been accepted by the maternal