随着新生儿重症监护技术和治疗手段的改进,早产儿和极低出生体重儿的存活率得以显著提高。早在40年前就有使用糖皮质激素促胎肺成熟的报道,目前临床上在产前、产后使用不同类别、剂量、疗程的激素来预防和干预早产儿尤其是极低出生体重儿疾病仍是研究的热点。糖皮质激素是由肾上腺皮质中层束状带分泌的一类甾体类化合物,因其调节糖类代谢的活性最早 Survival of preterm and very low birth weight children has increased significantly with improvements in neonatal intensive care and treatment. As early as 40 years ago, glucocorticoid was used to promote fetal lung maturation. At present, different types, doses and treatment hormones are used prenatal and postnatal to prevent and interfere with preterm infants, especially those with very low birth weight Is the hot spot of research. Glucocorticoids are a class of steroidal compounds secreted by the middle adrenal cords, which have the earliest activity of regulating carbohydrate metabolism