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目的探讨分析雌激素受体(ER)β在乳腺癌中的调控作用。方法选取2008年06月~2013年6月本院收治的52例乳腺癌患者作为研究对象,从其乳腺组织中获取标本,对样本ER表达和相关临床参数进行检测。结果 52例样本中ER阳性表达率为65.4%。ER的表达和患者肿瘤大小、浸润范围、月经情况、临床分期、P53等表达无明显关系(P>0.05);与病理分型、Ki67有相关性(P<0.05)。结论 ER和乳腺癌细胞增殖存在一定关系。
Objective To investigate the role of estrogen receptor (ER) beta in the regulation of breast cancer. Methods Fifty-two patients with breast cancer who were treated in our hospital from June 2008 to June 2013 were selected as subjects. Specimens were obtained from their breast tissues and the expression of ER and related clinical parameters were detected. Results The positive expression rate of ER in 52 samples was 65.4%. The expression of ER was not significantly related to tumor size, invasive range, menstrual status, clinical stage, P53, etc. (P>0.05). It was correlated with pathological type and Ki67 (P<0.05). Conclusion There is a certain relationship between ER and breast cancer cell proliferation.