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中国医院药学杂志,2015,35(2):95~99.茶碱类药物在临床治疗中应用广泛,是临床治疗支气管哮喘和慢性阻塞性肺疾病的主要药物,还有明显的利尿、降低肺动脉压、增强膈肌功能及黏液清除等作用。近年来发现氨茶碱对急性缺氧动物吸氧后再缺氧损伤有预防作用,但茶碱类药物的治疗剂量与中毒剂量相当接近,安全范围较窄,稍不慎就有可能引起中毒。本文通过对平原与急进4 100m高原后氨茶碱在大鼠体内药动力学差异性进行比较研究,旨在为不同海拔下制定氨茶碱给药剂量提供有力证据。作者选取健康雄性Wistar
Chinese Hospital Pharmacy, 2015,35 (2): 95 ~ 99. Theophylline drugs in the clinical treatment of a wide range of clinical treatment of bronchial asthma and chronic obstructive pulmonary disease, the main drug, as well as significant diuretic, pulmonary artery reduction Pressure, enhance diaphragmatic function and mucus clearance and so on. In recent years, aminophylline was found to be effective in preventing hypoxia injury after acute oxygen deficient animals were exposed to oxygen. However, the theophylline treatment dose was quite close to the poisoning dose, with a narrower range of safety and less risk of poisoning. In this paper, we compared the pharmacokinetics of aminophylline in the plains and the rapid 4 100 m plateau in rats in order to provide strong evidence for the formulation of aminophylline doses at different altitudes. The author selects healthy male Wistar