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目的探讨Cerb-B-2在胃癌组织中的表达及其与P53的相关性。方法随机选取我院2008年1月-2012年6月确诊为胃癌组织75例,并选取癌旁组织15例为对照组,检测cerb-B-2在胃癌组织中的表达及与临床病理的相关性,并分析其与突变型P53单薄阳性表达的相关性。结果 Cerb-B-2在胃癌组织的阳性率为61.33%,显着高于正常对照组(6.67%),差异有统计学意义(P<0.05);Cerb-B-2的阳性表达与胃癌患者年龄、性别、肿瘤直径等无相关性(P>0.05),而与肿瘤的分化程度、TNM分期及淋巴结转移相关(P<0.05)。在胃癌组织中Cerb-B-2的表达与P53具有正相关性(χ2=5.84,P<0.05)。结论 Cerb-B-2在胃癌中高表达,且与肿瘤细胞的凋亡相关,有望成为胃癌诊断和治疗的重要靶点。
Objective To investigate the expression of Cerb-B-2 in gastric carcinoma and its relationship with P53. Methods A total of 75 cases of gastric cancer were selected from January 2008 to June 2012 in our hospital and 15 cases of adjacent tissues were selected as the control group. The expression of cerb-B-2 in gastric cancer tissue was detected and correlated with clinical pathology Sex, and analyze its correlation with the diminished positive expression of p53. Results The positive rate of Cerb-B-2 in gastric cancer was 61.33%, which was significantly higher than that in normal control (6.67%) (P <0.05). The positive expression of Cerb-B-2 in gastric cancer Age, sex, tumor diameter and so on (P> 0.05), but not with the degree of tumor differentiation, TNM stage and lymph node metastasis (P <0.05). The expression of Cerb-B-2 in gastric cancer tissues was positively correlated with P53 (χ2 = 5.84, P <0.05). Conclusion Cerb-B-2 is highly expressed in gastric cancer and is related to the apoptosis of tumor cells, which may be an important target for the diagnosis and treatment of gastric cancer.