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本文用耗竭—补充—耗竭的设计,以克山病病区低硒粮饲料(含硒0.006ppm)喂养大鼠6周后,观察了补充紫阳高硒小麦(含硒1.175ppm)或亚硒酸钠,使饲料含硒分别为0.219和0.223ppm时,以及停止补硒后,大鼠组织和血液硒水平和谷胱甘肽过氧化物酶(GSH-px)活性的变化,并评估了紫阳高硒小麦的相对生物利用率。结果表明,以血浆、红细胞、肾、肝和心肌硒水平为指标时,高硒小麦硒的平均生物利用率(补硒2、4和6周时)与亚硒酸钠相似,其相对生物利用率分别为98％,104％,100％,96％和101％(亚硒酸钠为100％);而以心肌和红细胞GSH-Px活性为指标时,其生物利用率(90％和70％)低于亚硒酸钠。但在补硒的各时期,血液和各组织对高硒小麦硒的相对生物利用率不尽相同。此外,在停止补硒3周时,高硒小麦维持心、肝和红细胞硒水平以及心肌GSH-Px活性的作用优于亚硒酸钠。
In this study, the rats were fed with low-selenium diet (containing 0.006ppm selenium) in Keshan disease ward for 6 weeks after depletion-replenishment-depletion design. The effects of supplementing Ziyang high-selenium wheat (containing selenium 1.175ppm) or selenious acid Sodium, the feed selenium were 0.219 and 0.223ppm, respectively, and selenium was stopped after selenium in rats and blood levels of selenium and glutathione peroxidase (GSH-px) activity changes, and to assess the Ziyangao Relative Bioavailability of Selenium Wheat. The results showed that the average bioavailability of selenium in high-selenium wheat (selenium at 2, 4 and 6 weeks of seeding) was similar to that of sodium selenite with selenium levels in plasma, erythrocyte, kidney, liver and myocardium as indices, and its relative bioavailability The bioavailability (90% and 70%) of myocardial and erythrocyte GSH-Px activity was 98%, 104%, 100%, 96% and 101% ) Is lower than sodium selenite. However, in each period of selenium supplement, the relative bioavailability of selenium in high-selenium wheat is different for blood and tissues. In addition, the selenium level of heart, liver and erythrocyte, and GSH-Px activity in myocardium were higher than that of sodium selenite when selenium was stopped for 3 weeks.