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目的了解幼兔胎粪吸入后肺组织中血栓素Ｂ２（ＴＸＢ２）和６－酮前列环素１α（６—ｋｅｔｏ－ＰＧＦ１α）的动态变化。方法将动物分为轻度胎粪吸入组（１６ ｈ，２４ ｈ，４８ ｈ，７２ ｈ）、重度胎粪吸入组和对照组，通过气管内灌入胎粪０．６ ｍｌ／ｋｇ和 ４ ｍｌ／ｋｇ建立轻、重度幼兔胎粪吸入模型；应用右心室穿刺法经压力传感器与日本光电公司生产ＲＭ－６０００型多道生理记录仪相连，测定右心室收缩压；应用放射免疫法检测肺组织中ＴＷ和６－ｋｅｔｏ－ＰＧＦ１α含量。结果轻度胎粪吸入组右心室收缩压从胎粪吸入后 １６ ｈ升高（２ ５７± ０． １０ ｋＰａ）， ２４ ｈ达高峰（３． ５７± ０．１４ｋＰａ），７２ ｈ恢复正常（１．８９± ０． １４ ｋＰａ）。重度胎粪吸入组右心室收缩压（４． ３６± ０． １４ ｋＰａ）明显高于轻度胎粪吸入组和对照组（１．８５±０．０５ ｋＰａ）；轻度幼兔胎粪吸入１６ ｈ肺组织ＴＸＢ２（１５３．８０±１５．３７ ｐｇ／ｍｌ）和６－ｋｅｔｏ－ＰＧＦ１α（１１７．４０±２２．８８ｐｇ／ｍｌ）水平开始增高，２４ｈ达高峰（３６．９００±２８．８０ｐｇ／ｍｌ；２０７．２０±２８．５９ｐｇ／ｍｌ），至７２ｈ开始降低（ １０３．２０± ?
Objective To investigate the dynamic changes of thromboxane B2 (TXB2) and 6-keto-prostacyclin-1α (6-keto-PGF1α) in the lung tissue of young rabbits with meconium aspiration. Methods Animals were divided into mild meconium aspiration group (16 h, 24 h, 48 h, 72 h), severe meconium aspiration group and control group. The animals were infused intratracheally with 0.6 ml / kg of meconium and 4 ml / Kg to establish mild and severe rabbit meconium aspiration model; right ventricular puncture by pressure sensor with the Japan photoelectric company produced RM-6000 multi-channel physiological recorder connected to measure the right ventricular systolic pressure; radioimmunoassay detection of lung tissue Middle TW and 6-keto-PGF1α levels. Results Right ventricular systolic pressure in mild meconium aspiration group increased from 16 h after meconium aspiration (257 ± 0. 10 kPa) to peak at 24 h (3. 57 ± 0. 14 kPa), and returned to normal at 72 h .89 ± 0.14 kPa). Right ventricular systolic pressure (4.36 ± 0.14 kPa) in severe meconium aspiration group was significantly higher than that in mild meconium aspiration group and control group (1.85 ± 0.05 kPa); mild infant meconium aspiration 16 h, the levels of TXB2 (153.80 ± 15.37 pg / ml) and 6-keto-PGF1α (117.40 ± 22.88pg / ml) ; 207.20 ± 28.59pg / ml), and began to decrease at 72h (103.20 ±