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本文对甘肃３个基本控制病点和３个相对较重病点，进行气象环境、居住状况、饮水和粮食卫生学质量、经济收入及硒营养等项目流行病学对比调查，以探讨导致大骨节病下降的可能因素。结果表明，粮食卫生学质量和饮水质量的改善、部分地区居民居住状况改变、经济收入增加和硒水平提高与病情下降有一定关系。但任何单一因素都难以成为导致病情下降的唯一原因，而是诸因素共同作用的综合效应。为此，提倡和坚持以补硒为主的综合措施是当前防治大骨节病的较佳选择。
In this paper, three basic control points and three relatively serious disease points in Gansu, meteorological environment, living conditions, drinking water and food hygiene quality, economic income and selenium nutrition projects such as epidemiological investigation to explore leading to Kashin-Beck disease Declining factors. The results showed that the quality of food hygiene and drinking water quality improvement, residential living conditions in some areas change, increased economic income and increased levels of selenium and the disease has a certain relationship. However, any single factor can hardly become the only reason leading to the decline of the disease, but the combined effect of the various factors. To this end, to promote and adhere to the comprehensive measures of selenium-based prevention and control of the current Kashin-Beck disease is a better choice.