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目的 探讨糖皮质激素受体 (GR)数对预测糖皮质激素 (GC)疗效的价值。方法 30例重症肌无力 (MG)患者 ,采用3 H 地塞米松放射配体法测定外周血单个核细胞 (PBMC)GR数目 ,依据临床相对评分法评价GC治疗后 1、6个月疗效 ,其中 2 4例于GC治疗期间动态观察GR数的变化。结果 治疗前GR数与治疗后 1、6个月临床相对评分间呈良好的正相关关系 (r=0 916和r =0 891,P <0 0 1)。治疗前GR数越高 ,临床相对评分越高 ,GC疗效越好。GC治疗后GR数降低。结论 用药前测定GR数可以作为预测GC治疗反应、确定治疗方案的一个指标。GC治疗可使GR数下调。
Objective To investigate the value of glucocorticoid receptor (GR) in predicting the efficacy of glucocorticoid (GC). Methods Thirty patients with myasthenia gravis (MG) were treated with 3 H dexamethasone radioligand to determine the number of peripheral blood mononuclear cells (PBMCs). The clinical relative score was used to evaluate the effect of 1, 6 months after GC treatment 24 cases of dynamic changes in the number of GR during GC treatment. Results There was a positive correlation between the number of GR before treatment and the clinical relative score at 1 and 6 months after treatment (r = 0 916 and r = 0 891, P 0 01). The higher the GR number before treatment, the higher the relative clinical score, the better the GC efficacy. GR number decreased after GC treatment. Conclusion The determination of GR before treatment can be used as a predictor of GC response to treatment, to determine an indicator of treatment. GC treatment can reduce the number of GR.