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虽然钙拮抗剂尤其是短效钙拮抗剂的降压等心血管作用确切 ,但是在降低发病率和死亡率 ,改善病人生活质量方面并不令人满意。追溯性分析发现 ,在评价钙拮抗剂的有效性时 ,并未开展严格的、前瞻性的、随机的和对照的试验观察。更让人担忧的是 ,近年来有研究表明钙拮抗剂可能会增加癌症发生的危险性。因此 ,在广泛使用钙拮抗剂的今天 ,对钙拮抗剂的有效性和安全性的反思是十分必要的。
Although cardiovascular effects such as antihypertensive effects of calcium antagonists, especially short-acting calcium antagonists, are not exact, they are not satisfactory in reducing morbidity and mortality and improving patient quality of life. Retroactive analysis found no rigorous, prospective, randomized, and controlled trial to evaluate the effectiveness of calcium antagonists. More worrying is that in recent years, studies have shown that calcium antagonists may increase the risk of cancer. Therefore, in the wide use of calcium antagonists today, the validity and safety of calcium antagonists is a reflection of the very necessary.