肺血管上分布着多种钾通道 ,它们决定着膜静息电位 ,调节血管紧张性。患有肺动脉高压的机体 ,其肺血管上存在钾通道基因表达和功能异常 ,而钾通道功能状况与肺血管收缩、增生、重构密切相关。了解两者相辅相成的关系 ,有利于了解肺动脉高压形成机制 ,并为肺动脉高压治疗提供依据。 Pulmonary vascular distribution of a variety of potassium channels, they determine the membrane resting potential, regulate vascular tone. Pulmonary hypertension in the body, the presence of potassium channel gene expression and dysfunction in the pulmonary vessels, and potassium channel function and pulmonary vasoconstriction, proliferation, remodeling are closely related. To understand the complementary relationship between the two is conducive to understanding the formation mechanism of pulmonary hypertension, and provide the basis for the treatment of pulmonary hypertension.