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目的:了解我院严重药品不良反应(ADR)发生的特点和规律,为临床安全、合理用药提供参考。方法:对我院2007～2010年收集的51例严重ADR报告,分别从患者的性别、年龄、给药途径、药品种类及临床表现等方面进行统计、分析。结果:51例严重ADR报告中,中药注射剂所占比例最大(39.22%),其次为抗感染药物(21.57%),临床表现以全身性损害最多(54.54%),45例(88.23%)严重ADR由静脉滴注给药所致。结论:应重视严重ADR监测与报告,加强临床合理用药,以减少和避免严重ADR的发生。
Objective: To understand the characteristics and rules of serious adverse drug reaction (ADR) in our hospital and provide references for clinical safety and rational drug use. Methods: Fifty-one patients with severe ADR collected in our hospital from 2007 to 2010 were statistically analyzed from the aspects of patient’s sex, age, route of administration, drug type and clinical manifestation. Results: Among the 51 cases of serious ADR, the largest proportion of Chinese medicine injection (39.22%) was followed by anti-infective drugs (21.57%), the most common clinical manifestations were systemic injury (54.54%) and 45 cases (88.23%) with severe ADR Caused by intravenous infusion. Conclusion: Pay attention to monitoring and reporting of severe ADR and strengthen the rational use of clinical medicine to reduce and avoid the occurrence of severe ADR.