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目的观察联合应用前列腺素E1(PGE1,凯时)和羟苯磺酸钙(安多明)对马兜铃酸肾病(AAN)的临床疗效。方法于2003—2005年对中国医科大学附属第一医院的46例慢性AAN患者随机分为对照组20例(PGE1)和治疗组26例(PGE1和羟苯磺酸钙),观察2组治疗前后及组间相关指标的变化。结果治疗后治疗组和对照组患者血肌酐比治疗前明显下降(分别为P<0·01及P<0·05),血红蛋白比治疗前明显升高(分别为P<0·01及P<0·05),治疗组比对照组更明显。结论联合应用PGE1和羟苯磺酸钙可以缓解AAN患者肾功能损伤。
Objective To observe the clinical effect of combined use of prostaglandin E1 (PGE1, Kay) and calcium dobesilate on aristolochic nephropathy (AAN). Methods A total of 46 patients with chronic AAN from the First Affiliated Hospital of China Medical University from 2003 to 2005 were randomly divided into control group (PGE1) and treatment group (PGE1 and calcium dobesilate). Twenty-two patients And changes in the relevant indicators between groups. Results After treatment, serum creatinine in treatment group and control group decreased significantly (P <0.01 and P <0.05, respectively) and hemoglobin was significantly higher than that before treatment (P <0.01 and P < 0.05), the treatment group more obvious than the control group. Conclusions Combined use of PGE1 and calcium dobesilate can relieve renal dysfunction in patients with AAN.