论文部分内容阅读
①目的 了解肾脏病病人红细胞免疫功能和血清可溶性白细胞介素-2受体(sIL—2R)水平的变化。②方法 采用红细胞花环实验和双抗体夹心ELISA法,检测了53例肾脏病病人红细胞C_3b受体花环率(E-C_3bRR)、红细胞C_3b花环形成促进率(RFER)和抑制率(RFIR)、循环免疫复合物(CIC)、红细胞免疫复合物花环率(E-ICR)和sIL-2R水平的变化。③结果肾脏病病人E-C_3bRR,RFER明显低于对照组,而CIC,E-ICR,RFIR和sIL-2R明显高于对照组,差异均具有极显著性(t＝3.011~4.650,p均<0.01)。尿毒症病人以上各检测指标的变化较慢性肾炎病人更明显(t＝3.626~4.535,p均<0.001)。④结论肾脏病病人血清sIL—2R水平升高和红细胞免疫功能降低与其病情严重程度有关。
Objective To investigate the changes of erythrocyte immune function and serum soluble interleukin-2 receptor (sIL-2R) in patients with kidney disease. Methods The erythrocyte rosette assay and double antibody sandwich ELISA were used to detect the expression of erythrocyte C_3b receptor rosette (E-C_3bRR), erythrocyte C_3b rosette formation rate (RFER) and inhibition rate (RFIR) in 53 patients with renal disease. (CIC), erythrocyte immune complex rosette rate (E-ICR) and sIL-2R levels. ③ Results E-C_3bRR and RFER in patients with kidney disease were significantly lower than those in control group, but CIC, E-ICR, RFIR and sIL-2R were significantly higher than those in control group (all P < 0.01). Uremia patients more than the detection of changes in patients with chronic nephritis more obvious (t = 3.626 ~ 4.535, p <0.001). ④ Conclusion Serum sIL-2R levels in patients with kidney disease and erythrocyte immune function decreased with the severity of the disease.