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目的:了解咸阳地区成年女性宫颈人乳头瘤病毒(HPV)感染情况,对HPV基因分型结果进行分析。方法:采用反向点杂交基因扩增方法,检测450例成年女性宫颈脱落细胞感染的HPV基因及分型。结果:共检出147例阳性者,HPV的感染率为32.7%,HPV亚型感染率差异有统计学意义(χ2=38.54,P<0.01);50岁以上女性高中危亚型的感染率明显高于49岁以下者(χ2=20.11,P<0.01),29岁以下女性低危亚型的感染率明显高于30岁以上者(χ2=16.28,P<0.01)。结论:咸阳地区成年女性高中危亚型HPV感染的主要型别依次为HPV16、58和CP8304,低危亚型感染以HPV43占优势,不同年龄段的女性感染HPV亚型不同,育龄期女性易出现混合感染,在HPV疫苗的研究中应关注亚洲常见的HPV58。
Objective: To understand the adult female cervical HPV infection in Xianyang and analyze the genotyping results of HPV. Methods: Reverse transcriptase gene amplification was used to detect HPV genotypes and genotypes in 450 adult female patients with cervical exfoliated cells. Results: A total of 147 positive cases were detected. The infection rate of HPV was 32.7%. The infection rate of HPV subtype was statistically significant (χ2 = 38.54, P <0.01). The prevalence of high-risk subtypes in women over 50 years old was significantly higher The prevalence of low-risk subtypes in women under 29 years old was significantly higher than that of those over 49 years old (χ2 = 16.28, P <0.01), higher than 49 years old (χ2 = 20.11, P <0.01). CONCLUSION: The main types of high-risk HPV subtype in adult female high school in Xianyang are HPV16,58 and CP8304, HPV43 predominates in low-risk subtypes, HPV subtypes are different in women of different ages, and women of childbearing age are prone to appear Mixed infection, in HPV vaccine research should pay attention to HPV58 common in Asia.