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目的报告1例口服脊髓灰质炎(脊灰)减毒活疫苗引起的疫苗相关麻痹型脊灰病例,为预防接种工作提供参考。方法由河北省疾病预防控制中心(CDC)在该省急性迟缓性麻痹(AFP)病例监测系统报告病例中进行病毒分离,发现脊灰病毒阳性标本送国家CDC鉴定,综合病例的流行病学、临床表现和实验结果,由省级专家组做出诊断鉴定。结果患儿为首次服苗,23d后出现麻痹,60d后双下肢残留麻痹,国家级实验室鉴定结果为Ⅱ型脊灰疫苗相关株。结论该病例诊断鉴定为口服脊髓灰质炎减毒活疫苗引起的疫苗相关麻痹型脊灰病例。
Objective To report a case of vaccine-related paralytic poliovirus caused by live attenuated oral polio (poliomyelitis) vaccine and provide a reference for vaccination. Methods The CDC of Hebei province was isolated from the reported cases in the AFP surveillance system of the province. The positive samples of poliovirus were sent to the national CDC for identification. The epidemiology of comprehensive cases, clinical Performance and experimental results, made by the provincial expert group diagnosis. Results The children were the first service-taking vaccine. Paralysis occurred after 23 days. Paralysis of both lower extremities left after 60 days. The results of the national laboratory were type II poliovirus-related strains. Conclusions This case was diagnosed as a case of vaccine-associated paralytic polio caused by live attenuated oral polio vaccine.