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以博莱霉素致大鼠肺纤维化为模型，动态观察肺组织病理与支气管肺泡灌洗液细胞学所见，探讨支气管肺泡灌洗的临床评价及炎性细胞在肺纤维化中的动态变化和作用。结果：肺组织病理所见与支气管肺泡灌洗液中的细胞成份变化在炎症过程中有其一致性；巨噬细胞和中性粒细胞首先出现于肺内，而淋巴细胞则继其后；给予博莱霉素后第１～７天（早期）的肺部病变以肺泡炎为主，而第１４天以后则进入慢性纤维化阶段。提示：ＢＡＬＦ细胞学改变能较准确地反映肺内细胞成分的变化，ＢＡＬ可作为一项重要的检测手段；中性粒细胞主要在急性肺损伤／肺泡炎期起作用，而淋巴细胞则在慢性纤维化阶段扮演重要角色。
To bleomycin-induced pulmonary fibrosis in rats as a model, dynamic observation of lung tissue pathology and bronchoalveolar lavage fluid cytology seen to evaluate the clinical evaluation of bronchoalveolar lavage and inflammatory cells in pulmonary fibrosis in the dynamic changes And role. RESULTS: Changes in lung tissue pathology and changes in cellular components in bronchoalveolar lavage fluid were consistent during inflammation; macrophages and neutrophils first appeared in the lung, whereas lymphocytes followed; Bleomycin 1 to 7 days (early) of the lung lesions with alveolitis-based, but after 14 days into the chronic phase of fibrosis. Hints: BALF cytology changes can more accurately reflect changes in the composition of the lung cells, BAL can be used as an important means of detection; neutrophils play a major role in acute lung injury / alveolitis, and lymphocytes in chronic Fibrosis stage plays an important role.