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目的:比较PGE1和西地那非对先天性心脏病(先心病)手术后肺动脉高压的影响。方法:总结29例先心病合并重度肺动脉高压手术后临床资料,17例应用PGE1,12例应用西地那非。检测用药前后肺动脉压力、体循环压力、血氧饱和度、动脉血氧分压、动脉血二氧化碳分压、吸入氧浓度的变化。结果:用药前后肺动脉压力、血氧饱和度、动脉血氧分压、吸入氧浓度方面的变化均具有统计学意义(P<0.01)。结论:两种药物均能有效降低患者肺动脉压力。但PGE1在降低肺动脉压力的同时,对体循环影响较大。另外,西地那非为口服剂型,使用更方便。因此,西地那非可作为治疗先心病手术后肺动脉高压的新选择。
Objective: To compare the effects of PGE1 and sildenafil on pulmonary hypertension after surgery for congenital heart disease (CHD). Methods: The clinical data of 29 cases with congenital heart disease complicated with severe pulmonary hypertension were summarized, 17 cases were treated with PGE1 and 12 cases were treated with sildenafil. Before and after treatment, pulmonary arterial pressure, systemic pressure, oxygen saturation, arterial partial pressure of oxygen, partial pressure of arterial carbon dioxide and inhaled oxygen concentration were measured. Results: Before and after treatment, pulmonary arterial pressure, oxygen saturation, arterial partial pressure of oxygen and inhaled oxygen concentration had statistical significance (P <0.01). Conclusion: Both drugs can effectively reduce pulmonary artery pressure in patients. However, PGE1 in reducing pulmonary artery pressure, the greater impact on the systemic circulation. In addition, sildenafil oral dosage forms, the use of more convenient. Therefore, sildenafil can be used as a new treatment for pulmonary hypertension after CHD surgery.