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作者等用3种环糊精(CyD,α-,β-,γ-)制备13种苯并二氮(艹卓)的包合物以期改进溶解度和溶解作用。此外,并制备安定-γ-CyD 的包合物,用兔口服给药法比较包合物与安定本身的吸收特性。包合物的制备系取环糊精和苯并二氮(艹卓)适量在水混合,搅拌7天后,滤取微晶,真空干燥48h,即得固体。以安定为例,粉末中安定与γ-CyD 比为2∶3,分
The authors prepared 13 benzodiazepine inclusion complexes with 3 cyclodextrins (CyD, α-, β-, γ-) to improve solubility and solubilization. In addition, an a-γ-CyD inclusion complex was prepared and the absorption characteristics of the inclusion complex and diazepam itself were compared with the oral administration method of rabbit. Preparation of inclusion complex was taken cyclodextrin and benzodiazepine (艹 Zhuo) the right amount of water mixed, stirred for 7 days, the filter is crystallized, vacuum dried 48h, to obtain a solid. To stability, for example, the stability of the powder and γ-CyD ratio of 2: 3, points