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目的:研究慢性阻塞性肺病(COPD)大鼠气道粘蛋白Muc5ac和白介素13(IL-13)的表达及其相关性。方法:20只wistar雄性大鼠随机分为对照组和COPD组,正常组8只,COPD组12只,分别用免疫组化法测定肺组织Muc5ac和IL-13的表达。结果:Muc5ac和IL-13蛋白表达主要位于气道上皮细胞,细胞胞浆呈棕黄色。COPD组大鼠肺组织IL-13和Muc5ac的表达均高于正常组(P均<0.05)。结论:IL-13是引起粘液分泌的重要因子,它可能上调Muc5ac的表达。
AIM: To investigate the expression of interleukin Muc5ac and interleukin-13 (IL-13) in rats with chronic obstructive pulmonary disease (COPD) and their correlation. Methods: Twenty male Wistar rats were randomly divided into control group and COPD group. There were 8 normal rats and 12 COPD rats. The expressions of Muc5ac and IL-13 in lung tissue were detected by immunohistochemistry. Results: The expression of Muc5ac and IL-13 mainly located in airway epithelial cells with cytoplasm brownish yellow. The expression of IL-13 and Muc5ac in lung tissues of COPD rats were higher than those in normal rats (all P <0.05). Conclusion: IL-13 is an important factor that causes mucus secretion, which may up-regulate Muc5ac expression.