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维生素D中毒所致的高钙血症和尿钙增多,可用糖皮质激素治疗。患者女性,49岁,甲状腺次全切除术后长期(1971～75年)应用维生素D(100,000U/日)治疗。1975年10月,出现体重减轻、厌食、瘙痒、背痛及失眠、夜尿症等维生素D中毒症状。同年11月血清钙为14.2 mg/dl。停用维生素D后,血清钙仍为14.0到11.9mg/dl,磷为5.6到4.0mg/dl。随后,对患者进行2次研究评价。第1次在平衡情况下进行16天,每天摄取钙375mg。分4期,每期4天:第1期为对照平衡期;第2和3期为连续治疗期:口服强的松10mg,每6小时1次;第4期停服强的松。停用强的松后3周内高钙血症再发,进行持续8天的第2次研究:仍摄取钙375mg/日,4天后加用强的松5 mg,每日4次。第1次研究中,第1期平均血清钙为12.2±0.7mg/dl,第3和4期,分别下降到9.1±0.1和8.8±
Vitamin D poisoning caused by hypercalcemia and increased urinary calcium, available glucocorticoid treatment. Patients Female, 49 years old, treated with vitamin D (100,000 U / day) for long term (1971-75) after subtotal thyroidectomy. October 1975, there weight loss, anorexia, itching, back pain and insomnia, nocturia and other symptoms of vitamin D poisoning. The same year in November serum calcium was 14.2 mg / dl. After discontinuing vitamin D, serum calcium remained at 14.0 to 11.9 mg / dl and phosphorus at 5.6 to 4.0 mg / dl. Subsequently, two study evaluations of patients were performed. The first time in equilibrium at 16 days, daily intake of calcium 375mg. Divided into 4, each 4 days: the first phase of the control period of balance; the second and third period of continuous treatment period: oral prednisone 10mg, every 6 hours 1; Hypercalcemia was relapsed within 3 weeks after prednisone was discontinued and a second study lasting 8 days was performed: 375 mg of calcium was still administered, and prednisone 5 mg 4 times daily after 4 days. In the first study, mean serum calcium of the first phase was 12.2 ± 0.7 mg / dl and decreased to 9.1 ± 0.1 and 8.8 ± s at phases 3 and 4