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目的对比泮托拉唑与奥美拉唑治疗消化道溃疡出血的疗效。方法选取80例消化道溃疡患者,随机分为两组,观察组静脉滴注泮托拉唑,对照组静脉滴注奥美拉唑,两组均治疗7 d。观察并记录两组患者治疗后的疗效、治疗前后胃液p H值、出血时间、住院时间及出血量和治疗期间不良反应情况,评价奥美拉唑与泮托拉唑治疗消化道溃疡出血的疗效及安全性。结果观察组有效率92.7%,对照组有效率89.7%,两组治疗有效率无明显差异;但观察组显效率(85.4%)明显高于对照组(56.4%),差异有统计学意义(P<0.05)。治疗前两组胃液呈酸性,p H值相比无统计学差异,治疗后两组胃液p H有所提高,观察组胃液p H值高于对照组,差异有统计学意义(P<0.05)。观察组患者住院时间、止血时间均短于对照组,差异有统计学意义(P<0.05);出血量明显少于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患者不良反应明显少于对照组,差异有统计学意义(P<0.05)。结论泮托拉唑与奥美拉唑均适用于消化道溃疡出血的治疗,但泮托拉唑抗酸和止血效果更好,药物安全性更高,值得临床推广使用。
Objective To compare the efficacy of pantoprazole and omeprazole in the treatment of peptic ulcer bleeding. Methods Eighty patients with peptic ulcer were randomly divided into two groups. The observation group received intravenous infusion of pantoprazole, while the control group received intravenous infusion of omeprazole, both of which were treated for 7 days. The curative effect of the two groups of patients after treatment, p H value of gastric juice before and after treatment, bleeding time, length of hospital stay, blood loss and adverse reactions during the treatment were observed and recorded. The curative effect of omeprazole and pantoprazole in the treatment of peptic ulcer bleeding was evaluated And safety. Results The effective rate was 92.7% in observation group and 89.7% in control group, but there was no significant difference between the two groups. However, the effective rate in observation group was significantly higher than that in control group (85.4% vs 56.4%, P <0.05). The gastric juice of the two groups before treatment was acidic, p H value compared with no significant difference, p value of gastric juice increased after treatment, the p value of gastric juice in the observation group was higher than that of the control group, the difference was statistically significant (P <0.05) . The observation group patients hospitalization time, bleeding time shorter than the control group, the difference was statistically significant (P <0.05); bleeding was significantly less than the control group, the difference was statistically significant (P <0.05). During the treatment, adverse reactions in the observation group were significantly less than those in the control group, the difference was statistically significant (P <0.05). Conclusions Both pantoprazole and omeprazole are suitable for the treatment of peptic ulcer bleeding. However, pantoprazole has better antacid and hemostatic effects and higher drug safety, which is worthy of clinical promotion.