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作者以放射免疫法(RIA)测定了666名接种3针乙型肝炎疫苗的医务人员的抗-HBs几何平均滴度(GMT)。95.8%的人应答良好(抗-HBs≥36RIA单位),GMT高达6300。28人(4.2%)应答不佳,其中8人呈低应答(8～16RIA单位),20人无应答(<8RIA单位)。18±4个月后,这些人重新接种3针疫苗。结果表明,低应答和无应答组中17人(61%)抗-HBs>36RIA单位(最终应答组),其中低应答组8人全部阳转,但GMT仅为应答良好组的1/10(621∶6300)。经9个月随访,抗体均未消失。无应答组20人,接种6针疫苗后仍有
The authors determined the anti-HBs geometric mean titer (GMT) of 666 medical staff vaccinated with a 3-dose hepatitis B vaccine by radioimmunoassay (RIA). Ninety-five percent of responders responded well (anti-HBs ≥ 36 RIA units), and GMTs of 6300.28 (4.2%) did not respond well. Eight of them had low response (8-16 RIA units) and 20 nonresponders (<8 RIA units ). After 18 ± 4 months, these people were re-vaccinated with a 3-dose vaccine. The results showed that anti-HBs> 36RIA units (final response group) were 17 (61%) in the low-response and no-response groups, with 8 of the low-response groups all being positive, but the GMT was only 1/10 621: 6300). After 9 months of follow-up, antibodies did not disappear. No response group of 20 people, still vaccinated 6 vaccines