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目的:初步探究清热化痰法指导下的蒌芩止嗽煎对慢性阻塞性肺病急性加重期(AECOPD)大鼠血清中性粒细胞弹性蛋白酶水平的影响。方法:建立大鼠AECOPD模型,60只AECOPD大鼠模型随机分为模型对照组(20只)、氨溴索组(20只)、蒌芩止嗽煎组(20只),用酶联免疫吸附法(ELISA)测定AECOPD大鼠模型治疗前后血清中中性粒细胞弹性蛋白酶(NE)指标。结果:蒌芩止嗽煎组、氨溴索组治疗后与治疗前比较,NE均有明显下降(P<0.01)。结论:清热化痰法指导下的蒌芩止嗽煎初步研究是通过降低NE水平,从而减少AECOPD大鼠模型的气道黏液高分泌,减轻气道阻塞。
Objective: To investigate the effect of Qingqinzhihao Decoction under the guidance of Qingre Huatan method on the level of serum neutrophil elastase in rats with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: AECOPD model was established in rats. Sixty AECOPD rats were randomly divided into model control group (n = 20), ambroxol group (n = 20) The serum neutrophil elastase (NE) was measured by ELISA before and after treatment with AECOPD. Results: The scores of NE in all groups were significantly decreased (P <0.01) after treatment with Shuqin Zhoutuo decoction and ambroxol group before treatment. CONCLUSION: The preliminary study of Qutan Zhoupou Decoction under the guidance of the method of clearing away heat and dissipating phlegm can reduce airway mucus hypersecretion and airway obstruction by decreasing the level of NE in AECOPD rat model.