肌萎缩侧索硬化(ALS)是一种病因及发病机理均不太明确的疾病。近年来积累的资料表明,体液免疫与本病的发生有关。在病人血清中,先后发现有免疫球蛋白量的改变;血中发现有免疫复合物。肾活检发现有免疫复合物沉积。虽然在脑脊液(C-SF)中未检出免疫复合物(ICs),但在病人的脑组织中证实有IgG 沉积,并存在补体C_3、C_4。在一些病人的CSF 中,发现存在寡克隆(oligoclonal)免疫球蛋 Amyotrophic lateral sclerosis (ALS) is a disease and pathogenesis are not clear disease. The accumulated data in recent years show that humoral immunity is related to the occurrence of this disease. In the patient’s serum, it was found that there was a change in the amount of immunoglobulin; blood was found to have immune complexes. Kidney biopsy found immune complex deposition. Although immune complexes (ICs) were not detected in cerebrospinal fluid (CSF), deposition of IgG was confirmed in the patient’s brain and complement C_3 and C_4 were present. In some patients’ CSF, the presence of oligoclonal immunoglobulin was found