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42名患有细菌性脑膜炎的婴幼儿(平均年龄为2岁半)在刚入院治疗时,有83%患者的脑脊髓液(CSF)样品中可检测到白细胞介素-6(IL-6)的活性(>50U/ml),其平均值为36500±49580U/ml。当患者接受治疗时,CSF中的IL-6的活性有所上升,但48小时后,几乎测不到IL-6的活性。这可能是由于使用抗生素治疗的结果,抗生素会使细菌游离的内毒素和其他细胞壁组分迅述增加,从而导致溶菌,于是细胞素(cytokines)的产物增加。作者认为细胞间素是脑膜炎的中介体。28名患者用头孢三嗪噻(口亏)(100mg/kg/
42 infants and young children with bacterial meningitis (mean age 2 and a half) At the time of first hospitalization, interleukin-6 (IL-6) was detected in cerebrospinal fluid (CSF) samples from 83% of patients ) Activity (> 50 U / ml) with an average value of 36500 ± 49580 U / ml. The activity of IL-6 in CSF was increased when patients were treated, but almost no activity of IL-6 was detected after 48 hours. This may be due to the use of antibiotic treatment which results in a rapid increase of bacterial free endotoxin and other cell wall components leading to lysis and an increase in the production of cytokines. The authors suggest that intercellular elements are meningitis intermediates. 28 patients with cefotaxime thiophene (mouth loss) (100mg / kg /