NFK-κB是一种重要的核转录因子,由一个复杂的体系组成。近年来的研究表明,NF-κB在肿瘤的抗凋亡机制中起着至关重要的作用。目前研究发现NF-κB与口腔鳞癌的发生、发展和侵袭密切相关。NF-κB的激活是肿瘤细胞抵抗TNF介导的细胞凋亡的重要机制,而抑制NF-κB的激活可以导致肿瘤细胞的大量凋亡。通过基因治疗来抑制NF-κB的活性,再辅以常规的化疗将有望成为一种治疗口腔鳞癌的有效方法。 NFK-κB is an important nuclear transcription factor, composed of a complex system. Recent studies have shown that NF-κB plays a crucial role in the anti-apoptotic mechanisms of tumors. The current study found that NF-κB and oral squamous cell carcinogenesis, development and invasion are closely related. Activation of NF-κB is an important mechanism for tumor cells to resist TNF-mediated apoptosis. However, the inhibition of NF-κB activation can lead to a large number of apoptosis in tumor cells. By gene therapy to inhibit the activity of NF-κB, combined with conventional chemotherapy is expected to be an effective method for the treatment of oral squamous cell carcinoma.