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目的 研究Ａｌｚｈｅｉｍｅｒ 病（ＡＤ） 、血管性痴呆（ＶＤ） 和健康老年人（ＮＡ） 的神经心理学和功能性影像学特征及两者的相关性。方法 对３６ 例ＡＤ、３５ 例ＶＤ 患者和３７ 名ＮＡ 进行神经心理学评定和脑血流灌注显像。结果 ＡＤ 和ＶＤ 患者各量表成绩显著低于ＮＡ，ＡＤ 的物品记忆测验成绩（ＦＯＭ）显著低于ＶＤ。ＡＤ 和ＶＤ患者大部分脑区放射性计数比值（ＲＡＲ）明显低于ＮＡ，ＡＤ右顶叶和双额叶的ＲＡＲ明显低于ＶＤ。ＮＡ的ＦＯＭ 与多个脑区的ＲＡＲ 相关，ＡＤ 多项量表成绩与右顶叶ＲＡＲ相关，ＶＤ多项量表成绩与左顶叶ＲＡＲ相关。结论 左、右顶叶血流灌注下降分别对ＶＤ 和ＡＤ 的认知缺损有较大影响，提示ＶＤ 和ＡＤ分别具有不同的左、右半球机制
Objective To investigate the neuropsychological and functional imaging features of Alzheimer’s disease (AD), vascular dementia (VD) and healthy elderly (NA) and their relationship. Methods Neuropsychological assessment and cerebral perfusion imaging were performed in 36 AD patients, 35 VD patients and 37 NA patients. Results The scales of AD and VD were significantly lower than those of NA. The item memory test scores (FOM) of AD were significantly lower than those of VD. The ratio of radioactive count (RAR) in most brain regions of patients with AD and VD was significantly lower than that of NA. The RAR of right parietal lobe and double frontal lobe of AD patients was significantly lower than that of VD. The FOM of NA was correlated with RAR of multiple brain regions. The results of AD multi-item scale were related to right parietal RAR. VD multi-item scale scores were associated with left parietal RAR. Conclusion The decrease of perfusion in the left and right parietal lobes has a significant effect on the cognitive deficits of VD and AD, respectively, suggesting that VD and AD have different mechanisms of left and right hemispheres