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目的:探讨黄芪注射液联合阿糖腺对小儿手足口病患者血清中炎症因子水平等相关指标影响。方法:选取2014年8月—2016年8月医院收治的手足口病患儿108例为研究对象,随机分为观察组与对照组。对照组患者在常规治疗的基础上给予阿糖腺苷治疗,观察组在对照组的基础上联合黄芪注射液治疗,对比两组患儿的临床疗效、临床症状消退时间、平均住院时间,并在治疗前后检测患儿血清白细胞介素-10(IL-10)、白细胞介素1β(IL-1β)、心脏肌钙蛋白1(c Tn I)及肿瘤坏死因子α(TNF-α)的水平。结果:观察组患儿的总有效率为94.44%,对照组患儿的总有效率为77.78%,与对照组对比,观察组患儿的总有效率明显降低,差异有统计学意义(P<0.05);与对照组对比,观察组患儿的退热时间、口腔溃疡愈合时间、皮疹消退时间、食欲好转时间及住院时间均明显缩短,差异有统计学意义(P<0.05);治疗前,两组患儿IL-10、IL-1β、c Tn I、TNF-α水平无明显差异(P>0.05),与治疗前对比,治疗后两组患儿IL-10、IL-1β、c Tn I、TNF-α水平均明显降低,且观察组患儿的IL-10、IL-1β、c Tn I、TNF-α水平水平较对照组降低更明显,差异有统计学意义(P<0.05)。结论:黄芪注射液联合单磷酸阿糖腺苷治疗手足口病患儿临床疗效显著,并能显著改善患儿血清中炎症因子水平,安全性高,值得临床推广应用。
Objective: To investigate the effects of astragalus injection combined with acinus gland on the related indexes of serum inflammatory cytokines in children with hand-foot-mouth disease. Methods: A total of 108 children with HFMD admitted to our hospital from August 2014 to August 2016 were selected as study subjects and randomly divided into observation group and control group. The patients in the control group were treated with valauronine on the basis of routine treatment. The observation group was treated with astragalus injection on the basis of the control group, and the clinical efficacy, clinical symptom subsided time and average length of stay in the two groups were compared. The levels of serum IL-10, IL-1β, cTn I and TNF-α were measured before and after treatment. Results: The total effective rate was 94.44% in the observation group and 77.78% in the control group. Compared with the control group, the total effective rate in the observation group was significantly lower (P < 0.05). Compared with the control group, the antipyretic time, ulcer healing time, rash subsidence time, appetite improvement time and hospitalization time in the observation group were significantly shortened (P <0.05). Before treatment, The levels of IL-10, IL-1β, cTn I and TNF-α in two groups had no significant difference (P> 0.05). Compared with those before treatment, the levels of IL-10, IL- (P <0.05). The level of IL-10, IL-1β, cTn I, TNF-α in the observation group was significantly lower than that in the control group . Conclusion: Astragalus injection combined with vidarabine monophosphate treatment of children with hand-foot-mouth disease has significant clinical efficacy, and can significantly improve the serum levels of inflammatory cytokines in children with high safety, worthy of clinical application.