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目的评价芬太尼与芬太尼联合异丙酚用于人工流产时的镇痛效果及安全性。方法 2010-08—2013-08我院门诊要求人工流产者366例,其中术中用芬太尼镇痛者167例,芬太尼100μg+5%葡萄糖4 mL(1 min),iv;用芬太尼+异丙酚镇痛者199例,首先给予芬太尼100μg,再给予异丙酚2 mg·kg-1,ivgtt。比较2组患者术中疼痛分级、阴道出血量、术后恶心呕吐及人工流产综合征的发生率等。结果芬太尼+异丙酚组患者术中镇痛效果明显好于单用芬太尼组(P<0.05);2组患者术中出血量,术后恶心呕吐及人工流产综合征发生率差别无统计学意义(P>0.05)。结论与单用芬太尼相比,芬太尼+异丙酚镇痛效果明显,且不增加药物不良反应。
Objective To evaluate the analgesic effect and safety of fentanyl and fentanyl in combination with propofol for induced abortion. Methods 2010-08-2013-08 In our hospital, 366 cases of induced abortion were required, including 167 cases of intraoperative fentanyl analgesia, 4 ml of fentanyl 100 μg + 5% glucose (1 min), iv In addition, 199 patients were treated with fentanyl and propofol. First, fentanyl 100 μg was given and then propofol 2 mg · kg -1, ivgtt. The incidence of intraoperative pain grade, vaginal bleeding, postoperative nausea and vomiting, and induced abortion syndrome were compared between the two groups. Results The analgesic effect of fentanyl + propofol group was better than that of fentanyl group alone (P <0.05). The difference of intraoperative blood loss, postoperative nausea and vomiting and incidence of induced abortion syndrome No statistical significance (P> 0.05). Conclusion Compared with fentanyl alone, fentanyl + propofol has obvious analgesic effect and does not increase adverse drug reactions.