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目的探讨重症监护室脓毒血症诊疗中应用血清降钙素原(PCT)和C反应蛋白(CRP)的效果。方法 125例脓毒血症患者作为观察组,根据脓毒血症严重程度分为轻度组60例、重度组40例、休克组25例;45例非脓毒血症患者作为对照组,对比各组血清CRP、PCT水平和急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分情况。结果 PCT、CRP和APACHEⅡ评分:轻度组分别为(0.26±0.11)ng/ml、(67.56±12.33)mg/L、(12.36±2.64)分;重度组分别为(2.35±0.24)ng/ml、(95.09±33.25)mg/L、(14.67±3.41)分;休克组分别为(10.99±1.34)ng/ml、(145.39±37.79)mg/L、(20.79±6.72)分;对照组分别为(0.03±0.02)ng/ml、(4.32±2.10)mg/L、(5.02±1.23)分。观察组各亚组血清CRP、PCT和APACHEⅡ评分均高于对照组(P<0.05);脓毒血症严重程度越高,其血清CRP、PCT和APACHEⅡ评分越高(P<0.05)。结论重症监护室脓毒血症诊疗中应用血清PCT和CRP效果显著,其能够有效反映患者脓毒血症严重程度,为临床诊断提供可靠依据。
Objective To investigate the effect of serum procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis and treatment of sepsis in intensive care unit. Methods 125 patients with sepsis as the observation group, according to the severity of sepsis were divided into mild group of 60 cases, severe group of 40 cases, shock group of 25 cases; 45 cases of non-sepsis patients as a control group, compared Serum levels of CRP, PCT and acute physiology and chronic health status score system Ⅱ (APACHE Ⅱ) score of each group. Results The scores of PCT, CRP and APACHEⅡwere (0.26 ± 0.11) ng / ml, (67.56 ± 12.33) mg / L and (12.36 ± 2.64) respectively in severe group and (2.35 ± 0.24) ng / ml in severe group , (95.09 ± 33.25) mg / L and (14.67 ± 3.41), respectively; while the levels in shock group were (10.99 ± 1.34) ng / ml and (145.39 ± 37.79) mg / L and (20.79 ± 6.72) (0.03 ± 0.02) ng / ml, (4.32 ± 2.10) mg / L, (5.02 ± 1.23) points respectively. Serum levels of CRP, PCT and APACHEⅡ in each subgroup of the observation group were significantly higher than those in the control group (P <0.05). Serum levels of CRP, PCT and APACHEⅡ were higher in the sepsis group (P <0.05). Conclusion Serum PCT and CRP are significantly effective in diagnosis and treatment of intensive care unit sepsis, which can effectively reflect the severity of sepsis in patients and provide a reliable basis for clinical diagnosis.