临床广泛应用的再灌注治疗评价指标主要针对的是心内膜下冠状动脉,近年来越来越多的证据表明,冠状动脉微循环在心肌的血供中起着重要作用。有些急性心肌梗死患者,虽然通过血流重建治疗使梗死相关冠脉开通,但由于相关的冠脉微循环出现微栓塞,使近远期心血管事件发生率和死亡率增加;相反,另外一些急性心肌梗死患者虽然相关冠脉仍闭塞,但其灌注区的心肌微循环却可通过侧支循环得到灌注,预后良好。因此越来越多的临床医生开始关注微循环的灌注,出现了一系列针对微循环的评价指标。但是目前的技术尚无法在人体内直接观察微血管,微血管血流的测定也非常复杂,现回顾和展望微循环灌注的检测手段以及应用。 Clinical evaluation of reperfusion therapy is widely used in clinical subendocardial coronary artery, in recent years, more and more evidence that coronary microcirculation plays an important role in myocardial blood supply. In some patients with acute myocardial infarction, although infarction-related coronary arteries are opened by revascularization, there is an increase in the incidence of cardiovascular events and mortality in the near and distant phases due to micro-embolism in the relevant coronary microcirculation. On the contrary, some other acute Although patients with myocardial infarction related coronary artery occlusion, but its perfusion area myocardial microcirculation but perfusion through the collateral circulation, the prognosis is good. Therefore, more and more clinicians began to pay attention to microcirculation perfusion, there have been a series of evaluation indicators for microcirculation. However, the current technology is still not directly observed in the human capillaries, capillary blood flow measurement is also very complex, are reviewed and prospects of microcirculation perfusion detection methods and applications.