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活性氧(ROS)在有氧代谢中以中度水平持续产生,有利于产生氧化还原信号,但数量较大时却能引起氧化损伤和神经退行性病变。由于大脑对ROS敏感度提高,在不同类型神经细胞中保持正常氧化还原状态尤为重要。过去10年的研究充分说明:有规律的运动对大脑功能产生有益影响,并对中风、老年痴呆和帕金森症的预防和治疗起重要作用。然而,研究运动的具体影响似乎又非常复杂,包括通过神经营养因子的神经发生、毛细血管化增加、氧化损伤减少,以及通过蛋白酶和脑啡肽酶的蛋白降解增加。来自我们及其他实验室的数据表明,运动诱导的ROS水平调节对蛋白含量以及脑源性神经营养因子(BDNF)、酪氨酸激酶B(TrkB)、cAMP反应元件结合蛋白(CREB)的表达有重要作用,有利于完善脑功能、增加神经生成。因此,运动诱导的氧化还原状态调节是一种重要方式,运动能通过这一方式造福于大脑功能、增强对氧化应激的抵抗力,协助从氧化应激中恢复、减弱年龄相关的认知能力下降。
Reactive oxygen species (ROS) are produced continuously at a moderate level in aerobic metabolism, which is good for generating redox signals. However, a large amount of them can cause oxidative damage and neurodegenerative diseases. Due to the increased sensitivity of the brain to ROS, it is particularly important to maintain normal redox status in different types of nerve cells. Research over the past decade has fully demonstrated that regular exercise has a beneficial effect on brain function and plays an important role in the prevention and treatment of stroke, dementia and Parkinson’s disease. However, the specific effects of studying exercise seem to be very complex, including through neurogenesis of neurotrophic factors, increased capillarization, decreased oxidative damage, and increased protein degradation by proteases and neprilysin. Data from us and other laboratories indicate that exercise-induced ROS level modulation has an effect on protein content and expression of BDNF, TrkB and CREA Important role, help improve brain function, increase neurogenesis. Thus, exercise-induced regulation of redox status is an important way in which exercise can benefit brain function in this way, increase resistance to oxidative stress, assist in recovery from oxidative stress, and diminish age-related cognitive abilities decline.