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轻度缺碘时随补硒和缺硒时间延长大鼠甲状腺重量和甲状腺过氧化物酶（ＴＰＯ）活力均逐渐增加，但缺硒（Ｓｅ↓）组增加幅度大；血清Ｔ４含量先降低后升高，Ｔ３含量逐渐增加，ｒＴ３含量呈逐渐降低的趋势。补硒（Ｓｅ↑）组肝脏、肾脏Ⅰ型脱碘酶（ＩＤＩ）活力先增加后降低，Ｓｅ↓组逐渐降低。甲状腺ＩＤＩ活力两硒组均有增加趋势，但Ｓｅ↓组低于Ｓｅ↑组的增加幅度。Ｓｅ↓组大脑Ⅱ型脱碘酶（ＩＤⅡ）活力有降低的趋势。提示低硒可降低肝脏和肾脏ＩＤＩ活力；硒缺乏可加重碘缺乏的效应；实验期间甲状腺代偿性增加Ｔ３分泌，这可能是甲状腺ＩＤＩ起主要作用。
Thyroid weight and thyroid peroxidase (TPO) activity gradually increased with prolonged selenium supplementation and selenium deficiency in mild iodine deficiency, but increased in selenium deficiency group (Se ↓); serum T4 decreased first and then increased High, T3 content gradually increased, rT3 content showed a gradual downward trend. Selenium (Se ↑) group liver and kidney activity of type Ⅰ deiodinase (IDI) first increased and then decreased, Se ↓ group decreased. Thyroid IDI activity increased in both selenium groups, but the Se ↓ group was lower than that in the Se ↑ group. Se ↓ group Ⅱ brain deiodinase (ID Ⅱ) activity decreased. The results suggest that low selenium can reduce liver and kidney IDI activity; selenium deficiency can aggravate the effect of iodine deficiency; thyroid compensatory increase T3 secretion during the experiment, which may be the main role of thyroid IDI.