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目的测定2型糖尿病并发冠心病患者对氧磷酯酶-1(PON1)活性和丙二醛水平。方法分别采用紫外分光光度法和比色法测定正常对照组(NC组,n=40)、单纯糖尿病组(DM组,n=47)及糖尿病并发冠心病组(DMCHD组,n=43)血清PON1活性及丙二醛(MDA)水平,计算并测定体质量指数(BMI)及血脂水平。结果3组间比较,血脂水平差异无统计学意义(P>0.05);与NC组、DM组比较,DMCHD组BMI增大(P均<0.05)。DM组及DMCHD组PON1活性均低于NC组,MDA水平均高于NC组(P均<0.05),DMCHD组PON1活性低于DM组,MDA水平高于DM组(P均<0.05)。且PON1活性与MDA水平呈负相关(r=-0.544,P<0.01)。结论血清PON1活性降低和MDA水平升高是糖尿病并发冠心病的独立危险因素。
Objective To determine the activity of paraoxonase-1 (PON1) and the level of malondialdehyde in type 2 diabetic patients with coronary heart disease. Methods Ultraviolet spectrophotometry and colorimetric method were used to detect the serum levels in normal control group (NC group, n = 40), simple diabetic group (DM group, n = 47) and diabetes complicated with coronary heart disease group (DMCHD group, n = 43) PON1 activity and malondialdehyde (MDA) levels were calculated and measured body mass index (BMI) and blood lipid levels. Results Compared with NC group and DM group, BMI in DMCHD group increased (P <0.05). There was no significant difference in blood lipid levels between the three groups (P> 0.05). PON1 activity in DM group and DMCHD group was lower than that in NC group, and MDA level was higher than NC group (P <0.05). PON1 activity in DMCHD group was lower than that in DM group. MDA level was higher than DM group (P <0.05). PON1 activity was negatively correlated with MDA level (r = -0.544, P <0.01). Conclusions The decrease of serum PON1 activity and the increase of MDA level are independent risk factors of diabetes complicated with coronary heart disease.