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用A组溶血性链球菌特异性菌膜抗原作为刺激物,测定94例风湿任心脏炎患者外周血淋巴细胞促凝血活性(prcoagulantactivity,PCA),阳性率为82.98%,高于血沉(ESR)、C反应蛋白(CRP)、循环免疫复合物(CIC)、抗心肌抗体(AHRA)和抗链“O”(ASO)的阳性。本研究还测定了90例健康人、60例静止期风湿热、20例急性风湿性关节炎、94例其它疾病的PCA值作比较。证明该试验在诊断风湿性心脏炎具有较好的特异性(特异度为88.30%)。研究提示:①PCA是目前诊断风湿性心脏炎最有价值的检测方法;②体液免疫和细胞免疫共同参与风湿性心脏炎发病机制,而细胞免疫可能占更为重要的地位。
A group of hemolytic streptococcus specific membrane antigens as stimuli, determination of 94 patients with rheumatic heart disease peripheral blood lymphocyte procoagulantactivity (PCA), the positive rate was 82.98%, higher than the ESR (ESR ), C-reactive protein (CRP), circulating immune complex (CIC), anti-myocardium antibody (AHRA) and anti-chain “O” The study also compared the PCA values of 90 healthy individuals, 60 patients with quiescent rheumatic fever, 20 with acute rheumatoid arthritis and 94 other diseases. Proves that the test in the diagnosis of rheumatic carditis has a good specificity (specificity of 88.30%). The research suggests: (1) PCA is the most valuable method for the diagnosis of rheumatic carditis; (2) humoral and cellular immunity are involved in the pathogenesis of rheumatic carditis, and cellular immunity may occupy a more important position.