[Objective]To explore the preparation process of PERICARPIUM GRANATI effervescent granules.[Method]Taking the content of total flavonoids as an index,the ultrasonic extraction process of PERICARPIUM GRANATI was optimized by means of L 9(3 4) orthogonal test with ethanol concentration,extraction times,solid-liquid ratio,extraction temperature as experimental factors.Refined extract and adjuvants were mixed to prepare effervescent granules.The angle of repose,moisture content,dissolubility,and particle size of effervescent particles were detected.[Result]The optimum ultrasonic extracting conditions of PERICARPIUM GRANATI were as follows:solvent of 70% ethanol,extraction times of 1,extraction time of 30 min and solid-liquid ratio of 1:25(g /ml).The formula of effervescent granules was established as follows:PERICARPIUM GRANATI thick paste 10 g,lactose 74 g,cane sugar 4 g,citric acid 3 g,sodium bicarbonate 25 g,polyethylene glycol 6000 14 g,70% ethanol.The angle of repose of effervescent granules was 29.6° and showed good liquidity.The moisture content,the particle size and the dissolubility of granules conformed to the pharmacopoeia stipulation.[Conclusion]The preparation process is simple,and the quality is stable and controllable,so it is fit for industrialized production of PERICARPIUM GRANATI effervescent granules. [Objective] To explore the preparation process of PERICARPIUM GRANATI effervescent granules. [Method] Taking the content of total flavonoids as an index, the ultrasonic extraction process of PERICARPIUM GRANATI was optimized by means of L 9 (34) orthogonal test with ethanol concentration , extraction times, solid-liquid ratio, extraction temperature as experimental factors. Refined extract and adjuvants were mixed to prepare effervescent granules. The angle of repose, moisture content, dissolubility, and particle size of effervescent particles were detected. ultrasonic extracting conditions of PERICARPIUM GRANATI were as follows: solvent of 70% ethanol, extraction times of 1, extraction time of 30 min and solid-liquid ratio of 1:25 (g / ml). The formula of effervescent granules was established as follows : PERICARPIUM GRANATI thick paste 10 g, lactose 74 g, cane sugar 4 g, citric acid 3 g, sodium bicarbonate 25 g, polyethylene glycol 6000 14 g, 70% ethanol. The angle of repose of effervescent g ranules was 29.6 ° and showed good liquidity.The moisture content, the particle size and the dissolubility of granules conformed to the pharmacopoeia stipulation. [Conclusion] The preparation process is simple, and the quality is stable and controllable, so it is fit for industrialized production of PERICARPIUM GRANATI effervescent granules.