Objectives To observe theprofile of the serum levels of inflammatory cytokinesinterleukin-6(IL-6) , tumor necrosis factor (TNF-α) andinterleukin-10 (IL-10) and evaluate the effects ofangiotensin- converting enzyme inhibitor-Captopril onthem in renohypertensive rats. Methods Using reformedtwo-kidney-one-clip(2K1C)method, renal hypertensiverats (RHR) were obtained by ligating abdominal aorta.30 Wistar rats were randomized into three groups;sham-operation group(A) ,model control group(B) andcaptopril group (C). All rats were killed after beinggiven the trial drugs 5 weeks, ELISA assays were usedto detect the levels of IL-6 and IL-10, the levels ofTNF-alpha were measured with radioimmunoassays.Results compared with group A, the left ventricularhypertrophy was aggravated in group B significantly,the ratio of left ventricle and body weight (LV/BW) was0.00318 ±0.00030 (B)and 0.00256 ±0.00040 (A)respectively (P < 0.001), the levels of IL-6 and TNF-αincreased significantly (P < 0.001 and P< 0.002respectively), whereas the levels of IL-10 were notchanged between the two groups (P > 0.05);compared with group B, the LV/BW was 0.00266±0.00018 (C) and 0.00318±0.00030 (B) respectively(P< 0.001), the levels of IL-6 and TNF-α decreasedsignificantly ( P < 0.01), whereas the levels of IL-10were not changed between the two groups (P > 0.05);Conclusions Angiotensin converting enzymeinhibitor-captopril can lower the serum levels of pro-inflammatory cytokines IL-6 and TNF-α effectively,but can not increase the levels of anti-inflammatorycytokine IL-10, it suggests that captopril may have afeature to prevent or slow the development ofhypertensive complications by means of lowering thelevels of pro-inflammatory cytokines but not byincreasing anti-inflammatory cytokine IL-10. Objectives To observe the profile of the serum levels of inflammatory cytokinesinterleukin-6 (IL-6), tumor necrosis factor (TNF-α) and interleukin-10 (IL-10) and evaluate the effects of angiotensin- converting enzyme inhibitor-captopril onthem in renohypertensive rats . Methods Using reformedtwo-kidney-one-clip (2K1C) method, renal hypertensiverats (RHR) were obtained by ligating abdominal aorta. 30 Wistar rats were randomized into three groups; sham-operation group (A) All rats were killed after being given the trial drugs for 5 weeks, ELISA assays were used to detect the levels of IL-6 and IL-10, the levels of TNF-alpha were measured with radioimmunoassays. Results compared with group A, the left ventricular hypertype was aggravated in group B significantly, the ratio of left ventricular and body weight (LV / BW) was 0.00318 ± 0.00030 (B) and 0.00256 ± 0.00040 (A) respectively (P <0.001) 6 and TNF-αincreased significantly (P <0.001 and P < 0.002respectively), compared with group B, the LV / BW was 0.00266 ± 0.00018 (C) and 0.00318 ± 0.00030 (B) respectively (P <0.05) 0.001), the levels of IL-6 and TNF-α decreased significantly (P <0.01), while the levels of IL-10were not changed between the two groups (P> 0.05); Conclusions Angiotensin converting enzyme inhibitor-captopril can lower the serum levels of pro-inflammatory cytokines IL-6 and TNF-α effectively, but can not increase the levels of anti-inflammatory cytokine IL-10, it suggests that captopril may have afeature to prevent or slow the development of hypertensive syndrome by means of lowering the levels of pro -inflammatory cytokines but not byincreasing anti-inflammatory cytokine IL-10.