1963年Rubinstein和Taybi首先报道本病,第二年得到Coffin的证实,并提出这一命名。流行病学本综合征是引起智力低下的一个少见原因,几个英语国家的病例研究表明,在专门机构进行治疗的病人中每300名中约有一例,据估计约占需送专门机构治疗人群的 The disease was first reported by Rubinstein and Taybi in 1963, confirmed by Coffin the following year, and presented with the nomenclature. Epidemiology The syndrome is a rare cause of mental retardation. Case studies in several English-speaking countries show that about one out of every 300 patients treated in the specialized agencies is estimated to account for about a third of the total number of patients treated in specialized agencies of