论文部分内容阅读
研究与临床实践证实,脐带血造血干细胞相对于骨髓、外周血来源的造血干细胞更加原始,脐带血造血干细胞具有较强的自我更新、增殖分化、体外扩增等诸多优势。脐带血中的淋巴细胞没有受到外界抗原的刺激,免疫源性相对较弱。近几年,关于脐带血应用于血液病的治疗研究不断深入,本文作者从脐带血在治疗再生障碍性贫血、地中海贫血中的作用,脐带血移植治疗恶性血液病、脐带血辅助单倍型造血干细胞移植等几个方面进行了简要概述。
Research and clinical practice confirmed that umbilical cord blood hematopoietic stem cells are more primitive than bone marrow and peripheral blood derived hematopoietic stem cells. Umbilical cord blood hematopoietic stem cells have many advantages such as self-renewal, proliferation and differentiation, and in vitro expansion. Lymphocytes in umbilical cord blood are not stimulated by external antigens and are relatively weakly immunogenic. In recent years, umbilical cord blood on the application of hematological diseases continue to deepen the study, the author from the cord blood in the treatment of aplastic anemia, the role of thalassemia, umbilical cord blood transplantation for the treatment of hematologic malignancies, umbilical cord blood-assisted haplotype hematopoiesis Stem cell transplantation and other aspects of a brief overview.