论文部分内容阅读
自身免疫性疾病是临床常见的一类以免疫系统攻击自身组织为特征的疾病,其代表性疾病为系统性红斑狼疮(SLE)。临床一般采用免疫抑制疗法治疗此病,其依据是此类患者体内往往有自身免疫反应亢进,治疗目的是抑制这一自身免疫过程。但常用免疫抑制剂如糖皮质激素类(氢化考的松,地塞米松)及细胞毒类药物(环磷酰胺、硫唑嘌呤等)的作用范围极为广泛,对各类免疫活性细胞及其它正常组织细胞均有杀伤作用,选择性较差,影响了治疗效果。自身免疫病的过程是一个复杂的免疫调节紊乱过程,是体内辅助性细胞与抑制性细胞及其相关因子相互作用的一个调节失常过程。有的细胞处于功能超常态,有的则处于抑制态,理想的疗法应是选择性
Autoimmune diseases are a common clinical disease characterized by the immune system attacking their own tissues, the representative disease is systemic lupus erythematosus (SLE). Clinical immunosuppressive therapy is generally used to treat the disease, based on the fact that such patients often have autoimmune hyperactivity in vivo, the purpose of treatment is to suppress this autoimmune process. However, commonly used immunosuppressive agents such as glucocorticoids (hydrocortisone, dexamethasone) and cytotoxic drugs (cyclophosphamide, azathioprine, etc.) a very wide range of effects on various types of immune cells and other normal Tissue cells have killing effect, selectivity is poor, affecting the treatment effect. The process of autoimmune disease is a complex immunomodulatory disorder process that is a dysregulation of the interaction of helper cells with inhibitory cells and their associated factors in the body. Some cells in the supernormal state of function, while others are in inhibition, the ideal therapy should be selective